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1.

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.

Alwan, Sevan N; Taylor, Alexander B; Rhodes, Jayce; Tidwell, Michael; McHardy, Stanton F; LoVerde, Philip T.

PLoS Pathog ; 19(7): e1011018, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37428793

2.

Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.

Platt, Roy N; Le Clec'h, Winka; Chevalier, Frédéric D; McDew-White, Marina; LoVerde, Philip T; Ramiro de Assis, Rafael; Oliveira, Guilherme; Kinung'hi, Safari; Djirmay, Amadou Garba; Steinauer, Michelle L; Gouvras, Anouk; Rabone, Muriel; Allan, Fiona; Webster, Bonnie L; Webster, Joanne P; Emery, Aidan M; Rollinson, David; Anderson, Timothy J C.

Mol Ecol ; 31(8): 2242-2263, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35152493

3.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

Chevalier, Frédéric D; Le Clec'h, Winka; McDew-White, Marina; Menon, Vinay; Guzman, Meghan A; Holloway, Stephen P; Cao, Xiaohang; Taylor, Alexander B; Kinung'hi, Safari; Gouvras, Anouk N; Webster, Bonnie L; Webster, Joanne P; Emery, Aidan M; Rollinson, David; Garba Djirmay, Amadou; Al Mashikhi, Khalid M; Al Yafae, Salem; Idris, Mohamed A; Moné, Hélène; Mouahid, Gabriel; Hart, P John; LoVerde, Philip T; Anderson, Timothy J C.

PLoS Pathog ; 15(10): e1007881, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31652296

4.

Schistosomiasis.

LoVerde, Philip T.

Adv Exp Med Biol ; 1154: 45-70, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31297759

5.

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.

Taylor, Alexander B; Roberts, Kenneth M; Cao, Xiaohang; Clark, Nathaniel E; Holloway, Stephen P; Donati, Enrica; Polcaro, Chiara M; Pica-Mattoccia, Livia; Tarpley, Reid S; McHardy, Stanton F; Cioli, Donato; LoVerde, Philip T; Fitzpatrick, Paul F; Hart, P John.

J Biol Chem ; 292(27): 11154-11164, 2017 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-28536265

6.

The genome of the blood fluke Schistosoma mansoni.

Berriman, Matthew; Haas, Brian J; LoVerde, Philip T; Wilson, R Alan; Dillon, Gary P; Cerqueira, Gustavo C; Mashiyama, Susan T; Al-Lazikani, Bissan; Andrade, Luiza F; Ashton, Peter D; Aslett, Martin A; Bartholomeu, Daniella C; Blandin, Gaelle; Caffrey, Conor R; Coghlan, Avril; Coulson, Richard; Day, Tim A; Delcher, Art; DeMarco, Ricardo; Djikeng, Appolinaire; Eyre, Tina; Gamble, John A; Ghedin, Elodie; Gu, Yong; Hertz-Fowler, Christiane; Hirai, Hirohisha; Hirai, Yuriko; Houston, Robin; Ivens, Alasdair; Johnston, David A; Lacerda, Daniela; Macedo, Camila D; McVeigh, Paul; Ning, Zemin; Oliveira, Guilherme; Overington, John P; Parkhill, Julian; Pertea, Mihaela; Pierce, Raymond J; Protasio, Anna V; Quail, Michael A; Rajandream, Marie-Adèle; Rogers, Jane; Sajid, Mohammed; Salzberg, Steven L; Stanke, Mario; Tivey, Adrian R; White, Owen; Williams, David L; Wortman, Jennifer.

Nature ; 460(7253): 352-8, 2009 Jul 16.

Artigo em Inglês | MEDLINE | ID: mdl-19606141

7.

Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites.

Chevalier, Frédéric D; Valentim, Claudia L L; LoVerde, Philip T; Anderson, Timothy J C.

BMC Genomics ; 15: 617, 2014 Jul 21.

Artigo em Inglês | MEDLINE | ID: mdl-25048426

8.

Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels.

Corstjens, Paul L A M; De Dood, Claudia J; Kornelis, Dieuwke; Fat, Elisa M Tjon Kon; Wilson, R Alan; Kariuki, Thomas M; Nyakundi, Ruth K; Loverde, Philip T; Abrams, William R; Tanke, Hans J; Van Lieshout, Lisette; Deelder, André M; Van Dam, Govert J.

Parasitology ; 141(14): 1841-55, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24932595

9.

Identification of a new Schistosoma mansoni SMYB1 partner: putative roles in RNA metabolism.

Rocha, Elizângela A; Valadão, Analina F; Rezende, Cíntia M; Dias, Silvia Regina Costa; Macedo, Andréa M; Machado, Carlos R; Fantappié, Marcelo R; Rumjanek, Franklin D; Goes, Alfredo M; Gomes, Dawidson A; Loverde, Philip T; Drummond, Marcela G; Franco, Glória R.

Parasitology ; 140(9): 1085-95, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23673212

10.

Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA binding domains (2DBD-NRs).

Wu, Wenjie; LoVerde, Philip T.

PLoS One ; 18(9): e0286107, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37699039

11.

Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments.

Toth, Katalin; Alwan, Sevan; Khan, Susan; McHardy, Stanton F; LoVerde, Philip T; Cameron, Michael D.

Int J Parasitol Drugs Drug Resist ; 21: 65-73, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36758271

12.

Schistosome Sulfotransferases: Mode of Action, Expression and Localization.

Guzman, Meghan A; Rugel, Anastasia; Alwan, Sevan N; Tarpley, Reid; Taylor, Alexander B; Chevalier, Frédéric D; Wendt, George R; Collins, James J; Anderson, Timothy J C; McHardy, Stanton F; LoVerde, Philip T.

Pharmaceutics ; 14(7)2022 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-35890311

13.

Identification and evolution of nuclear receptors in Platyhelminths.

Wu, Wenjie; LoVerde, Philip T.

PLoS One ; 16(8): e0250750, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34388160

14.

The effect of fs800 on female egg production in Schistosoma mansoni.

Alwan, Sevan N; LoVerde, Philip T.

Mol Biochem Parasitol ; 245: 111412, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34492240

15.

Rational approach to drug discovery for human schistosomiasis.

LoVerde, Philip T; Alwan, Sevan N; Taylor, Alexander B; Rhodes, Jayce; Chevalier, Frédéric D; Anderson, Timothy Jc; McHardy, Stanton F.

Int J Parasitol Drugs Drug Resist ; 16: 140-147, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34111649

16.

Molecular basis for hycanthone drug action in schistosome parasites.

Guzman, Meghan; Rugel, Anastasia; Tarpley, Reid S; Cao, Xiaohang; McHardy, Stanton F; LoVerde, Philip T; Taylor, Alexander B.

Mol Biochem Parasitol ; 236: 111257, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-32027942

17.

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Rugel, Anastasia R; Guzman, Meghan A; Taylor, Alexander B; Chevalier, Frédéric D; Tarpley, Reid S; McHardy, Stanton F; Cao, Xiaohang; Holloway, Stephen P; Anderson, Timothy J C; Hart, P John; LoVerde, Philip T.

Int J Parasitol Drugs Drug Resist ; 13: 8-15, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32315953

18.

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

Guzman, Meghan A; Rugel, Anastasia R; Tarpley, Reid S; Alwan, Sevan N; Chevalier, Frédéric D; Kovalskyy, Dmytro P; Cao, Xiaohang; Holloway, Stephen P; Anderson, Timothy J C; Taylor, Alexander B; McHardy, Stanton F; LoVerde, Philip T.

PLoS Negl Trop Dis ; 14(8): e0008517, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32810153

19.

Nuclear hormone receptors in parasitic Platyhelminths.

Wu, Wenjie; LoVerde, Philip T.

Mol Biochem Parasitol ; 233: 111218, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31470045

20.

A unique nuclear receptor direct repeat 17 (DR17) is present within the upstream region of Schistosoma mansoni female-specific p14 gene.

Fantappié, Marcelo Rosado; Furtado, Daniel Rodrigues; Rumjanek, Franklin David; Loverde, Philip T.

Biochem Biophys Res Commun ; 371(4): 689-93, 2008 Jul 11.

Artigo em Inglês | MEDLINE | ID: mdl-18455507

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Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.

Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

Schistosomiasis.

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.

The genome of the blood fluke Schistosoma mansoni.

Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites.

Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels.

Identification of a new Schistosoma mansoni SMYB1 partner: putative roles in RNA metabolism.

Updated knowledge and a proposed nomenclature for nuclear receptors with two DNA binding domains (2DBD-NRs).

Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments.

Schistosome Sulfotransferases: Mode of Action, Expression and Localization.

Identification and evolution of nuclear receptors in Platyhelminths.

The effect of fs800 on female egg production in Schistosoma mansoni.

Rational approach to drug discovery for human schistosomiasis.

Molecular basis for hycanthone drug action in schistosome parasites.

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

Nuclear hormone receptors in parasitic Platyhelminths.

A unique nuclear receptor direct repeat 17 (DR17) is present within the upstream region of Schistosoma mansoni female-specific p14 gene.